Structure-based design of stapled peptides to target Gag-Pol and INI1 interaction to block assembly

Project: Research project

Project Details

Description

Project Narrative:
Despite advances in the treatment of HIV-1 infection, the AIDS pandemic remains
unabated and warrants the continued development of novel anti-HIV-1 therapeutics. Host-Virus
Protein/protein interactions (PPI) are viable therapeutic targets to develop novel anti-viral
reagents. Based on the newly discovered structure of INI1, an HIV-1 integrase binding host
protein, and based on the novel insights obtained of INI1’s molecular mimicry to HIV-1 TAR RNA,
we propose to develop stapled peptide inhibitors to intracellularly target IN-INI1 interactions.
These studies are likely to lead to the development of novel anti-viral biologics to inhibit HIV-1
particle production and/or particle morphogenesis.
StatusActive
Effective start/end date11/13/2010/31/22

Funding

  • National Institute of Allergy and Infectious Diseases: $211,312.00
  • National Institute of Allergy and Infectious Diseases: $271,500.00

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