NARRATIVE Radiation-induced gastrointestinal injury is a major cause of lethality from accidental or intentional exposure to whole body irradiation in the case of nuclear accidents or terrorism. Radiation injury occurring within days after exposure is classified as “acute injury” and often associated with direct damage to the stem cell and its niche, including the stroma and microvasculature. Late injury, which manifests months to years after exposure, is due to persistent oxidative and inflammatory signaling, aberrant stem cell regeneration, damage to the vascular stroma and scaring. Among various pharmacological approaches used, cell transplantation is one of the most effective strategies in treating radiation injury. The proposal delineate various strategies to optimize and enhance stromal cell therapy for the treatment of GI-ARS.
|Effective start/end date||3/9/18 → 2/28/23|
- National Institute of Allergy and Infectious Diseases: $2,287,989.00
- National Institute of Allergy and Infectious Diseases: $542,317.00
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