SORTING AND ASSEMBLY OF THE HSV-1 TEGUMENT PROTEIN VHS

Project: Research project

Project Details

Description

The Herpes viruses are responsible for a large number of human diseases.
All Herpes viruses possess a proteinaceous layer termed tegument which
lines the inner surface of the viral envelope. Correct assembly of
tegument and envelope is essential for the production of an infectious
virus particle, and thus for the progression of disease. However,
little is known of how tegument proteins recognize and bind to specific
cellular membranes, nor how they ensure their assembly into the maturing
virion.

This proposal will investigate membrane and tegument sorting information
present within the Herpes simplex virus (HSV) tegument protein vhs. We
will identify the cytoplasmic organelle which binds vhs, and determine
the role of this association in the HSV life cycle. Sequences
responsible for vhs/organelle binding will be identified, and we will
determine which regions of vhs ensure incorporation of this protein into
the mature virus. Information obtained from this study will help in the
design of agents able to interfere with vhs assembly into the HSV
particle, reducing the virulence of this serious human pathogen.
StatusFinished
Effective start/end date2/1/001/31/01

Funding

  • National Cancer Institute: $175,505.00

ASJC

  • Microbiology (medical)
  • Structural Biology
  • Virology
  • Cell Biology
  • Microbiology

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