SOMATIC CELL GENETICS OF IG GENES

Project: Research project

Project Details

Description

We will investigate the molecular mechanisms responsible for the tissue
specific and developmentally regulated hypermutation of immunoglobulin
variable region genes. This will be done by introducing manipulated
transfected genes into: 1) B cell lines whose endogenous immunoglobulin
genes are constitutively unstable or whose instability is triggered by T
cells and 2) transgenic mice. We will also study the role and impact of V
region mutations and isotype switching on the immune response to viruses
and fungi in normal mice and on the production of autoantibodies in lupus
prone autoimmune mice. We will study the role of affinity and avidity in
targeting to a model tumor system. We will use the insight gained from
these studies to generate antibodies that can be passively administered to
protect against HIV and cryptococcus infections and to target to drug
resistant tumors.
StatusFinished
Effective start/end date1/1/904/30/00

Funding

  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute

ASJC

  • Genetics
  • Molecular Biology

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.