SICKLE CELL ANEMIA &OTHER HEMOGLOBINOPATHIES

  • Skoultchi, Arthur I. (PI)
  • Elbaum, Danek (PI)
  • Peisach, Jack (PI)
  • Fabry, M. (PI)
  • Hirsch, Rhoda (PI)
  • Eisinger, Josef (PI)
  • Costantini, F. (PI)
  • Harrington, John (PI)
  • Kaul, D. (PI)
  • Baez, Silvio (PI)
  • Bookchin, R. (PI)
  • Nagel, Ronald (PI)
  • Tellez-Nagel, Isabel (PI)
  • Wittenberg, Jonathan (PI)
  • Nadel, Alfred (PI)
  • Roth, Eugene (PI)
  • Fabry, M. (PI)
  • Kaul, D. (PI)
  • Costantini, F. (PI)
  • Bookchin, R. (PI)

Project: Research project

Project Details

Description

The present project intends to advance the understanding of the molecular basis
of the polymerization of Hb S. We intend to investigate the pregelling events,
the role of non-Hb S molecules, and the supramolecular structure of the polymer. We intend to pursue the kinetics of sickling, the ligand kinetics of Hb S
containing red cells and the basis of the changes in the oxygen equilibrium
curve in these cells. We will continue the development of nitrogen mustards and
alkylureas as antisickling agents. We will also inquire into the basis of the
stimulation of the synthesis of Hb F in some pathological states, with the hope
of understanding its operative control.
StatusFinished
Effective start/end date6/1/825/31/92

Funding

  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute

ASJC

  • Medicine(all)

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