ROLE OF HERPESVIRUS COMPLEMENT-BINDING GLYCOPROTEIN

Project: Research project

Project Details

Description

The applicant plans to pursue a career in academic medicine and
biomedical research in the field of pediatric infectious diseases. The
long-term objective of the training program is for the applicant to
develop expertise in the field of molecular virology with particular
attention to the interactions of viruses with the immune system as a
basis for development of independent investigations. These skills will
be necessary to fully answer fundamental clinical questions such as the
role of viruses in oncogenesis and means of preventing the devastating
effects of viral infections in the immunocompromised host.

The specific training program planned includes course work in virology,
molecular biology, and immunology during phase I. the aims of the
research plan during phase I focus on the herpes simplex virus
glycoprotein termed gC and its importance in viral adsorption. This
glycoprotein is of special interest, in part because it is known to bid
directly to a human complement protein and to interact with the
complement cascade. Thus it offers a unique opportunity to examine the
interactions among the virus, target cells, and the hot immune system,
interactions that are undoubtedly important in viral pathogenesis. By
comparing various gC mutant viral strains with wild-type virus in
adsorption and infectivity assays, the biologic function of gC will be
defined. In phase II of the study, the effects of complement-binding on
viral adsorption and infectivity will be assessed. The knowledge gained
from these studies will help further formulate theories on viral
infectivity and may lead to promising new treatment modalities in the
management of herpesvirus infections.
StatusFinished
Effective start/end date1/1/907/31/90

Funding

  • National Institute of Allergy and Infectious Diseases

ASJC

  • Immunology

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