REGULATION OF NEUROPEPTIDE PROCESSING ENZYMES

Project: Research project

Project Details

Description

The research plan is focused on neuropeptide processing
carboxypeptidases. A major emphasis is on CPE, which has recently been
proposed to play a role in peptide sorting into the secretory vesicle.
We will evaluate this possibility using a variety of techniques.
Another major emphasis is on carboxypeptidase D (CPD), an enzyme we
recently discovered. It is likely that CPD processes peptides along
with CPE, and this will be addressed in our future studies. A third
area of emphasis is on three additional carboxypeptidase-like proteins
which we have recently discovered (CPZ, CPX1, and CPX2). We will
examine whether these novel proteins are able to process neuropeptides
such as enkephalin and dynorphin, as well as test other possible
functions.

The results of these studies will provide a better understanding of the
enzymes involved with peptide biosynthesis.
StatusFinished
Effective start/end date4/1/933/31/03

Funding

  • NATIONAL INSTITUTE ON DRUG ABUSE
  • NATIONAL INSTITUTE ON DRUG ABUSE
  • NATIONAL INSTITUTE ON DRUG ABUSE
  • NATIONAL INSTITUTE ON DRUG ABUSE: $115,464.00
  • NATIONAL INSTITUTE ON DRUG ABUSE: $125,388.00
  • NATIONAL INSTITUTE ON DRUG ABUSE
  • NATIONAL INSTITUTE ON DRUG ABUSE
  • NATIONAL INSTITUTE ON DRUG ABUSE: $125,388.00
  • NATIONAL INSTITUTE ON DRUG ABUSE
  • NATIONAL INSTITUTE ON DRUG ABUSE

ASJC

  • Structural Biology
  • Biochemistry
  • Cell Biology

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