Project: Research project

Project Details


The long-term objective for this project is to understand the
mechanisms involved in regulating coordinate gene expression during
cellular proliferation. Interleukin 2 stimulated T lymphocytes
will be used as a model to study cell cycle progression.
Specifically, the expression of cyclin, a proliferation associated
gene, during initial IL2-stimulated G1 activation, active pro-
liferation, and return to quiescence will be determined as will the
factors responsible for regulating cyclin expression. In addition,
other cell cycle dependent genes that regulated coordinately with
cyclin will be isolated. Molecular cytological techniques will be
used to carry out these studies. An understanding of the
regulation of genes that are required for normal cellular
proliferation should give us valuable insight into the pathobiology
of neoplasia.
Effective start/end date12/31/8911/30/91


  • Genetics
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Molecular Biology


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