• Flamm, Eugene S. (PI)
  • Ferris, Steven (PI)
  • Simon, Eric (PI)
  • Brodie, Jonathan (PI)
  • Wolf, Alfred (PI)
  • Fowler, Joanna (PI)

Project: Research project

Project Details


A proposal is presented to utilize tracers labeled with positron emitters and
positron emission transaxial tomographs (PETT) to carry out mapping of static
and dynamic functions of the brain. An immediate application will involve the
use of 18F-2-deoxy-2-fluoro-D-glucose (FDG) for measuring regional glucose
metabolism in a variety of normal and pathological states in the baboon and
human brain. In addition, this technique, pioneered by the University of
Pennsylvania in collaboration with BNL, will be applied to determining sites of
action in the brain related to specific drug intervention. A new aspect of the
application of this combination of research tools will be to develop useful
labeled agonists and antagonists and other psychotropic agents and apply them to
basic studies on opiate, dopaminergic, and other receptor action. Thus, for the
first time it may be possible to probe ligand-receptor interrelations in the
intact brain in a non-invasive and quantitative way. Other applications will
involve studies in anesthesia, enzyme mapping, and on the functional
architecture of the human visual cortex. Studies to determine the relation
between glucose metabolism and pathological state involve both the investigaion
of fundamental relationships and also effectiveness of treatment as mirrored in
metabolic activity.
Twelve studies are proposed ranging from those on animals alone to research with
human subjects involving both basic and clinical aspects. The clinical studies
include the development of heretofore inaccessible information on aging,
schizophrenia, and the relation of drug therapy to these states. Other clinical
studies will use these techniques to study rCGM and rCBF before and after drug
or surgical intervention, in treating patients with patent disease with the goal
of improving diagnosis and therapy. The majority of these studies require as an
essential aspect the improved spatial resolution of the newer PETT machines in
order to be effective. Thus, the proposal includes a request for such a machine
plus a request for modest cyclotron improvement in order to afford efficient
realization of this project.
Effective start/end date1/1/013/31/96


  • Clinical Neurology
  • Neurology
  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Signal Processing
  • Chemical Engineering(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Oncology
  • Cancer Research
  • Neuroscience(all)


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