Prometheus: A Platform for Rapid Development of Human Antibody-based Therapeutics and Prophylactics against Emerging Viral Threats

Project: Research project


The overarching goal of the Prometheus CETR is to discover and develop human antibody-based prophylactics and therapeutics against three major groups of Category A priority viruses that cause severe zoonotic disease?ebolaviruses, the nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV), and the hantaviruses Andes virus (ANDV), Sin Nombre virus (SNV), and Puumula virus (PUUV). Ebolaviruses, CCHFV, ANDV, and SNV are Category A agents that pose the highest risk to national security and public health. In their latest annual review, the World Health Organization desig- nated ebolavirus disease (EVD) and CCHF as Blueprint Priority Diseases with the greatest potential to cause a public health emergency. There are no approved vaccines or treatments for any of these agents. The Prometheus CETR, an interwoven collaboration among 11 partners from academia, gov- ernment, and industry, organized into three projects and three cores, will accomplish three Grand Goals that are each aimed at delivering a prophylactic or therapeutic product against our target viral pathogens. We will develop and deliver: (1) an antibody-based prophylactic with broad efficacy against ebolaviruses; (2) an antibody-based therapeutic with broad efficacy against CCHFV; (3) an antibody- based therapeutic with broad efficacy against the hantaviruses ANDV and SNV.
Effective start/end date2/14/191/31/24


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $4,348,829.00
  • National Institutes of Health


Monoclonal Antibodies
Crimean-Congo hemorrhagic fever virus
Sin Nombre virus
Rodent Diseases
Human Development
Biological Products
United States Food and Drug Administration
Security Measures
Public Health
Hantavirus Infections
Animal Disease Models


  • Medicine(all)
  • Immunology and Microbiology(all)