Prometheus: A Platform for Rapid Development of Human Antibody-based Therapeutics and Prophylactics against Emerging Viral Threats

Project: Research project

Description

The overarching goal of the Prometheus CETR is to discover and develop human antibody-based prophylactics and therapeutics against three major groups of Category A priority viruses that cause severe zoonotic disease?ebolaviruses, the nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV), and the hantaviruses Andes virus (ANDV), Sin Nombre virus (SNV), and Puumula virus (PUUV). Ebolaviruses, CCHFV, ANDV, and SNV are Category A agents that pose the highest risk to national security and public health. In their latest annual review, the World Health Organization desig- nated ebolavirus disease (EVD) and CCHF as Blueprint Priority Diseases with the greatest potential to cause a public health emergency. There are no approved vaccines or treatments for any of these agents. The Prometheus CETR, an interwoven collaboration among 11 partners from academia, gov- ernment, and industry, organized into three projects and three cores, will accomplish three Grand Goals that are each aimed at delivering a prophylactic or therapeutic product against our target viral pathogens. We will develop and deliver: (1) an antibody-based prophylactic with broad efficacy against ebolaviruses; (2) an antibody-based therapeutic with broad efficacy against CCHFV; (3) an antibody- based therapeutic with broad efficacy against the hantaviruses ANDV and SNV.
StatusActive
Effective start/end date2/14/191/31/24

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $4,348,829.00
  • National Institutes of Health

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Hantavirus
Ebolavirus
Monoclonal Antibodies
Antibodies
Crimean-Congo hemorrhagic fever virus
Nairovirus
Sin Nombre virus
Rodent Diseases
Human Development
Viruses
Biological Products
United States Food and Drug Administration
Primates
Security Measures
Public Health
Therapeutics
Rodentia
Hantavirus Infections
Animal Disease Models
Fever

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)