POSITRON EMITTERS AND PETT IN METABOLISM AND NEUROLOGY

  • Flamm, Eugene S. (PI)
  • Ferris, Steven (PI)
  • Simon, Eric (PI)
  • Brodie, Jonathan (PI)
  • Wolf, Alfred (PI)
  • Fowler, Joanna (PI)

Project: Research project

Project Details

Description

A proposal is presented to utilize tracers labeled with positron emitters and
positron emission transaxial tomographs (PETT) to carry out mapping of static
and dynamic functions of the brain. An immediate application will involve the
use of 18F-2-deoxy-2-fluoro-D-glucose (FDG) for measuring regional glucose
metabolism in a variety of normal and pathological states in the baboon and
human brain. In addition, this technique, pioneered by the University of
Pennsylvania in collaboration with BNL, will be applied to determining sites of
action in the brain related to specific drug intervention. A new aspect of the
application of this combination of research tools will be to develop useful
labeled agonists and antagonists and other psychotropic agents and apply them to
basic studies on opiate, dopaminergic, and other receptor action. Thus, for the
first time it may be possible to probe ligand-receptor interrelations in the
intact brain in a non-invasive and quantitative way. Other applications will
involve studies in anesthesia, enzyme mapping, and on the functional
architecture of the human visual cortex. Studies to determine the relation
between glucose metabolism and pathological state involve both the investigaion
of fundamental relationships and also effectiveness of treatment as mirrored in
metabolic activity.
Twelve studies are proposed ranging from those on animals alone to research with
human subjects involving both basic and clinical aspects. The clinical studies
include the development of heretofore inaccessible information on aging,
schizophrenia, and the relation of drug therapy to these states. Other clinical
studies will use these techniques to study rCGM and rCBF before and after drug
or surgical intervention, in treating patients with patent disease with the goal
of improving diagnosis and therapy. The majority of these studies require as an
essential aspect the improved spatial resolution of the newer PETT machines in
order to be effective. Thus, the proposal includes a request for such a machine
plus a request for modest cyclotron improvement in order to afford efficient
realization of this project.
StatusFinished
Effective start/end date9/1/858/31/86

Funding

  • National Institute of Neurological Disorders and Stroke

ASJC

  • Drug Discovery
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology
  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry
  • Genetics
  • Cellular and Molecular Neuroscience
  • Library and Information Sciences
  • Cognitive Neuroscience
  • Aging
  • Developmental Neuroscience
  • Nutrition and Dietetics
  • Visual Arts and Performing Arts
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nuclear Energy and Engineering
  • Pharmacology
  • Urban Studies

Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.