PHYSIOLOGY OF IL2-DRIVEN T-CELL GROWTH

Project: Research project

Project Details

Description

The proposed research is aimed at dissecting the physiological processes
that are required for IL2-driven proliferation of a murine cloned T cell
line, L2. This entails the characterization of pH and volume regulatory
mechanisms and assessment of membrane conductance. The primary approaches
used to investigate these research areas are I9F NMR, electronic cell
sizing and patch-clamp methods. Quiescent and IL2-stimulated L2 cells will
be characterized with respect to each of the aforementioned physiological
parameters. Additionally, these parameters will be assessed during
specific phases of the cell division cycle.
StatusFinished
Effective start/end date7/1/866/30/87

Funding

  • National Institute of General Medical Sciences

ASJC

  • Biophysics
  • Physiology
  • Biotechnology
  • Cell Biology
  • Pharmacology

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