PEPTIDE PROCESSING ENZYMES IN THE PLACENTA

Project: Research project

Project Details

Description

DESCRIPTION (Adapted from applicant's description): This K08 award will
allow the candidate to obtain the scientific expertise and to conduct
studies that will advance understanding of the functions of selected
placental peptidases. Specifically, she will test hypotheses about the
mechanisms by which alterations in the enzymes that process and metabolize
Endothelin-1 are related to the pathogenesis of pre-eclampsia and pre-term
labor and by which alterations in the carboxypeptidases that process a
variety of peptide hormones and growth restriction. Specific aim 1 will
test the hypothesis that two closely related metalloendopeptidases,
endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase (NEP),
function in the regulation of levels of endothelin-1 (ET-1) in the placenta
and that ET-1 functions as a common pathway in the pathogenesis of
pre-eclampsia and pre-term labor. Aim 2 will test the hypothesis that
recently identified members of the carboxypeptidase E family, highly
concentrated in the rat placenta, also function as peptide processing
enzymes in the human placenta. Specific aim 3 will test the hypothesis that
the novel placental proteins also have nonenzymatic functions.
StatusFinished
Effective start/end date4/1/983/31/99

Funding

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development

ASJC

  • Endocrine and Autonomic Systems
  • Molecular Medicine
  • Obstetrics and Gynecology
  • Biochemistry
  • Reproductive Medicine

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