Project: Research project

Project Details


Epidemiologic studies indicate that seizure disorders are more frequent
early in life. The objective of this international collaboration is to
identify the mechanisms involved in the suppression of seizures as a
function of age. Ongoing studies in the parent grant using the flurothyl
seizure model suggest that the increased seizure susceptibility of the
immature brain may be due to age-specific differences in the GABA(A)
receptor subtype within the substantia nigra, a site that is crucial for
the control of seizures in adults. This proposal takes advantage of the
expertise of the principal investigator and Dr. Mares, two pioneers in
the field of developmental epilepsy, and foster close international
collaboration between the two laboratories. The aim is to determine
whether the ontogenetic influence of the substantia nigra on seizures
depends on the model used to induce seizures. Methods include
intracranial localized microinfusions, systemic infusions of
chemoconvulsants, behavioral observations and EEG recordings. Rats of
various ages will be used to determine the maturational profile of the
substantia nigra-mediated seizure modification in the bicuculline and N-
methyl-D-aspartate model of epilepsy. These studies may lead to the
development of new therapeutic treatments that will compensate for the
maturational state of the CNS.
Effective start/end date4/1/933/31/95


  • Medicine(all)