Project Narrative (Public Health Relevance Statement) The epidemic of obesity has caused a prevalence of type 2 diabetes and other metabolic diseases in the United States and worldwide. Millions of Americans are now diagnosed with type 2 diabetes and the health care cost of diabetes is in billions of dollars each year. However, the molecular mechanisms underlying the regulation of energy metabolism remain poorly understood. This proposal will study a novel effector complex of insulin in the liver that controls gluconeogenesis and is involved in insulin resistance. The outcomes of this study will have significant and positive impacts in the field of metabolism and diabetes, and may also aid the development of new approaches for the treatment of type 2 diabetes.
|Effective start/end date||1/3/20 → 11/30/22|
- National Institute of Diabetes and Digestive and Kidney Diseases: $480,018.00
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