NEURONAL DEVELOPMENT, INTERACTION, AND ORGANIZATION

  • Spray, David C. (PI)
  • White, R.O.Y. (PI)
  • Saez, Juan (PI)
  • Hall, Linda (PI)
  • Ginzberg, Rosemary (PI)
  • Kessler, John (PI)
  • Bargiello, Thaddeus (PI)
  • Bennett, Michael V. L. (PI)
  • Hertzberg, Elliot (PI)
  • Verselis, Vyto (PI)
  • White, R.O.Y. (PI)
  • Hertzberg, Elliot (PI)
  • Verselis, Vyto (PI)

Project: Research project

Project Details

Description

Studies will be carried out on structure-function relations in electrotonic
junctions. Attention will be focused on mechanisms controlling channel
conductance and developmental aspects of junction formation. The development of
neuronal specificity of vestibular inputs to the Mauthner cells in the amphibian
CNS will be examined with respect to the topographic distribution of afferents
to regionally different components of the M-cell. Development and
pathophysiological consequences of meganeurite and secondary neurite formation
in pyramidal neurons, and caudate spiny neurons will be studied in feline
ganglioside storage disease. The cellular basis of calyceal function in the
vestibular semicircular canal system will be studied in lizards. Mechanisms of
transmitter release and synaptic interaction will be studied in the Mauthner
cell-giant fiber system of the hatchetfish. Other studies of interaction
involve morphophysiological analysis of brain stem connections with the
substantia nigra. Organizational aspects of the program will focus on the
neural substrate of feeding behavior in Navanax. Studies in this program will
employ combined electrophysiological, cell identification techniques and the use
of electron microscopy and freeze-fracture methods.
StatusFinished
Effective start/end date1/1/901/1/90

Funding

  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke

ASJC

  • Animal Science and Zoology
  • Endocrine and Autonomic Systems
  • Genetics(clinical)
  • Sensory Systems
  • Energy Engineering and Power Technology
  • Development
  • Genetics
  • Cellular and Molecular Neuroscience
  • Endocrinology
  • Periodontics
  • Developmental Neuroscience
  • Electrical and Electronic Engineering
  • Biophysics
  • Physiology
  • Anatomy
  • Computational Mechanics
  • Developmental Biology

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