Multi-center Evaluation of the Threat of Established and Emerging Respiratory Viral Infections in Pediatric Transplant Recipients

Respiratory viral infections are a leading source of infectious complications in children undergoing hematopoietic cell transplantation and solid organ transplantation. The current diagnostic methods do not distinguish true disease or predict patients at risk for progression to severe disease. We will use a multi-faceted approach focusing on the virus and the host response to define biomarkers that risk stratify patients and generate evidence- based pediatric guidelines for personalized management.