MOLECULAR TARGETING OF THERAPY FOR NERVOUS SYSTEM TUMORS

Project: Research project

Project Details

Description

Despite maximal currently available therapy, malignant brain tumors such
as glioblastoma are almost uniformly fatal. We plan to form a brain
tumor center with "Molecular targeting of therapy for nervous system
tumors" as its central theme. Our overall objective is to develop a
comprehensive center for basic research and innovative clinical care
aimed at understanding the molecular events associated with tumorigenesis
in the human nervous system and using this information to develop and to
test novel therapeutic strategies. The development of The Georgetown
Brain Tumor Center is strongly supported by the administration and links
two major developmental goals: cancer and the neurosciences.
Further it builds upon current strengths already at Georgetown,
such as the Lombardi Cancer Research Center.
Plans for administration, faculty recruitment, training,
and new program development are detailed. A research program is
presented which is focused on defining the molecular and biologic
differences between tumor cells and their normal nervous system
counterparts with particular attention toward molecular changes
associated with radiosensitivity, angiogenesis, growth, and the protein
kinase C system. This information will be used to devise molecular-based
strategies of therapy which include both new pharmaceutical approaches
as well as novel approaches such as the development and testing of viral
vectors. Four research projects are planned: 1) "Development of
genetically engineered viruses to treat malignant nervous system tumors";
2) "Molecular mechanisms of radiation resistance of malignant gliomas";
3) "Regulation of growth and differentiation of malignant pediatric and
adult brain tumors by protein kinase C"; 4) "Angiogenesis induced by
nervous system tumors: molecular mechanisms and therapeutic blockade".
Thus, we are developing a comprehensive center for clinical care,
training, basic research and novel therapeutic development and testing
in order to improve the treatment of people with brain tumors.
StatusFinished
Effective start/end date3/1/932/28/94

Funding

  • National Cancer Institute

ASJC

  • Drug Discovery
  • Cellular and Molecular Neuroscience
  • Endocrinology
  • Molecular Medicine
  • Developmental Neuroscience
  • Oncology
  • Cancer Research
  • Virology
  • Cell Biology
  • Endocrinology, Diabetes and Metabolism
  • Histology
  • Pharmacology
  • Pharmaceutical Science

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