Project Details
Description
Narrative:
Currently, a substantial effort is focused on understanding the mechanisms regulating the induction
of thermogenic beige adipocytes as a potential therapeutic target for increasing energy expenditure to
reduce and/or prevent obesity and insulin resistance. Although humans have the capacity to induce
thermogenic adipocytes, only 50% of adolescents and 10% of adults display cold inducible beige/brown
adipocytes. In contrast, all humans are born with brown adipose tissue that begins to decline during the
first decade of life and continues to decline throughout the normal lifespan. Similarly, brown adipose
depots in mice decline both in mass and function starting at approximately 8-12 months of age and
continue to decline throughout their remaining life span. Our preliminary data indicate that the decline
brown adipose tissue mass and function results the activation of a Nlrp1 pyroptosis cell death pathway
that is the focus of this new grant proposal.
Status | Active |
---|---|
Effective start/end date | 4/15/21 → 2/28/23 |
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases: $578,051.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $520,244.00
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