MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

Project: Research project

Project Details

Description

Primary hyperparathyroidism (HPT), a common endocrine disorder that can
cause significant morbidity, may be due to benign neoplasia of a
parathyroid gland (adenoma) or multiple parathyroid glands (hyperplasia),
and rarely, to malignant neoplasia of a parathyroid
gland (carcinoma). The etiology of parathyroid neoplasia has not been
defined. As with other forms of neoplasia, parathyroid tumors are
presumably due to inherited (germ-line mutation) and/or acquired (somatic
mutation) defects in specific genes. Etiologic genetic defects could
include inappropriate expression of transforming "oncogenes" and/or loss
of expression of tumor "suppressor" genes. The hereditary forms of
disease allows us to search for tumor-specific genetic abnormalities that
may be involved in development of parathyroid neoplasia.
StatusNot started

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases

ASJC

  • Genetics
  • Oncology
  • Cancer Research

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