MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

Project: Research project

Project Details

Description

Primary hyperparathyroidism (HPT), a common endocrine disorder that can
cause significant morbidity, may be due to benign neoplasia of a single
parathyroid gland (adenoma) or multiple parathyroid glands (hyperplasia),
and rarely, to malignant neoplasia of a parathyroid gland (carcinoma).
The etiology of parathyroid neoplasia has not been defined. As with
other forms of neoplasia, parathyroid tumors are presumably due to
inherited (germ-line mutation) and/or acquired (somatic mutation) defects
in specific genes. Etiologic genetic defects could include inappropriate
expression of transforming "oncogenes" and/or loss of expression of tumor
"suppressor" genes. The availability of surgically resected parathyroid
tumors from patients with sporadic and hereditary forms of disease allows
us to search for tumor-specific genetic abnormalities that may be
involved in development of parathyroid neoplasia.
StatusNot started

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases

ASJC

  • Oncology
  • Cancer Research

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