• Ruben, Robert J. (PI)
  • Bernstein, Richard (PI)
  • Schwartz, R. (PI)
  • Vaughn, Herbert (PI)
  • Stapells, David (PI)
  • Gravel, Judith (PI)
  • Kurtzberg, Diane (PI)
  • Vaughan, Herbert (PI)
  • Schwartz, R. (PI)
  • Stapells, David (PI)
  • Gravel, Judith (PI)
  • Kurtzberg, Diane (PI)
  • Vaughan, Herbert (PI)
  • Ruben, Robert J. (PI)
  • Ruben, Robert J. (PI)

Project: Research project

Project Details


Mismatch negativity (MMN) is an event related potential (ER)) elicited by
auditory stimuli that differ in one or more acoustic features from a train
of previously presented stimuli. MMN has been postulated to represent the
activity of an auditory comparator mechanism wherein a memory trace is set
up for the repetitive stimulus and the occurrence of a different sound
triggers neural activity signalling that change. MMN reflects activity
underlying an early, preattentive and automatic accoustic processing stage,
which makes it an ERP well suited as a probe of the auditory capabilities
of infants and young children. Since the appearance of MNN demonstrates
that the auditory system has the ability to detect a change in acoustic
stimulation, it holds the promise of providing 1) a powerful
electrophysiologic tool to study the limits of auditory discrimination
processing during development and 2) a probe of deviatn auditory
processing. The aims of this project are to determine the optimal
stimulating conditions under which MMN is present in newborns, infants and
children to tones and speech sounds; to define the spatiotemporal
characteristics of the response as a function of stimulus and age; to test
the predictive utility of MMN in a cohort of infants at risk for
speech/language and cognitive dysfunction; and to assess the clinical
correlation of MMN with acoustic processing dysfunction by testing a group
of children with phonemic processing disorders.
Effective start/end date1/1/016/30/02


  • Speech and Hearing
  • Acoustics and Ultrasonics
  • Language and Linguistics
  • Physiology
  • Linguistics and Language
  • Psychology(all)
  • Medicine(all)
  • Neuroscience(all)
  • Pediatrics, Perinatology, and Child Health


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