MICROENVIRONMENTS OF INVASION IN HUMAN BREAST TUMORS

Project: Research project

Project Details

Description

We have developed state-of-the-art methods necessary to observe tumor cell invasion and intravasation
directly in rat and mouse mammary tumors, correlate these cell behaviors with metastatic potential and
connect these behaviors to the gene expression patterns seen in the migratory and invasive subpopulation
of mammary tumor cells in the primary tumor. Furthermore, these methods can be used to characterize
microenvironments that cause autocrine and paracrine-mediated cell migration resulting in the accumulation
of cells around an initiating chemotactic signal, sometimes associated with blood vessels. This raises the
exciting possibility that there exist self-propagating autocrine and paracrine loops that are tumor grade
specific and that operate in the primary tumor, and possibly secondary and tertiary metastatic tumors, giving
rise to systemic invasion and metastasis. Extension of this new technology to human breast tumors will
allow us to explore the variety of stromal cells and microenvironments in this heterogeneous human tumor
that are involved in invasion and metastasis, and determine if a cohort of gene expression changes exists
as a common invasion signature that may have prognostic and therapeutic value.
The specific aims of the proposal are:
1. Identify microenvironments involved in invasion in human breast tumors.
2. Determine gene expression profiles of invasive cells in human breast tumors.
StatusFinished
Effective start/end date3/13/061/31/12

ASJC

  • Oncology
  • Cancer Research

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