Mechanisms of Methylmercury Induced Neuronal Toxicity

PROJECT NARRATIVE Methylmercury (MeHg) is a potent neurotoxin in both the developing and mature central nervous system with apparent indiscriminate disruption of multiple homeostatic pathways and evidence of latent and persistence and latent effects long after exposure has subsided. Here we seek to identify and understand persistent and latent effects of MeHg toxicity on biological pathways impacted by MeHg toxicity. We aim to determine if it is formally possible that latent neurotoxicity can be stopped before neurological signs appear or that established persistent effects that continue long after exposure has ceased could be reversed.