LIVER PATHOBIOLOGY AND GENE THERAPY RESEARCH CORE CENTER

  • Reid, Lola (PI)
  • Krauter, Kenneth (PI)
  • Shafritz, David (PI)
  • Roy-Chowdhury, Jayanta (PI)
  • Rogler, Charles E. (PI)
  • Satir, Brigit (PI)
  • Backer, Jonathan (PI)
  • Horwitz, Susan (PI)
  • Goldfischer, Sidney (PI)
  • Satir, Peter (PI)
  • Meier, U. Thomas (PI)
  • Davidson, Anne (PI)
  • Backer, Jonathan M. (PI)
  • Hays, Richard (PI)
  • Rogler, Leslie (PI)
  • Roy-Chowdhury, Jayanta (PI)
  • Rogler, Charles (PI)
  • Backer, Jonathan M. (PI)
  • Rogler, Charles E. (PI)
  • Meier, U. Thomas (PI)
  • Davidson, Anne (PI)
  • Hays, Richard (PI)
  • Rogler, Leslie (PI)
  • Roy-Chowdhury, Jayanta (PI)
  • Rogler, Charles (PI)

Project: Research project

Project Details

Description

The major objective is to understand fundamental mechanisms of normal
liver function, as well as alterations in these functions resulting form
diseases caused by metabolic, drug, metal, inheritable and viral agents.
Specific areas under study include transport processes, membrane receptor
biology, and structural-functional relationships; molecular biology,
somatic gene transfer and gene therapy, hepatic fibrosis and mechanisms
of hepatic carcinogenesis; liver cell metabolism, heavy metal metabolism,
mechanisms of liver injury and organelle pathology. By bringing
excellent basic scientists into disease-related research, together with
hematologists interested in fundamental mechanisms of hepatic
dysfunction, we believe that imaginative approaches to basic cell
biology, pathophysiology, diagnosis, treatment and prevention of liver
disease will emerge.

A large and diverse population provides many patients with viral,
alcoholic and parasitic liver disease, as well as various inheritable
disorders of the liver.
StatusFinished
Effective start/end date6/27/945/31/95

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases

ASJC

  • Applied Microbiology and Biotechnology
  • Gastroenterology
  • Transplantation
  • Genetics
  • Molecular Medicine
  • Developmental Neuroscience
  • Molecular Biology
  • Biophysics
  • Hematology
  • Structural Biology
  • Physiology
  • Biochemistry
  • Oncology
  • Biotechnology
  • Catalysis
  • Cell Biology
  • Toxicology
  • Biomaterials
  • Hepatology
  • Developmental Biology
  • Immunology

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