LIVER METABOLISM PROGRAM PROJECT

  • Goldman, I. David (PI)
  • Guzelian, Philip (PI)
  • Diegelmann, Robert (PI)
  • Lamb, Robert (PI)
  • Ruddy, Shaun (PI)
  • Fallon, Harold (PI)

Project: Research project

Description

The Liver Metabolism Program Project (LMPP) consists of a group of closely
related research projects concerned with metabolic functions of the hepatocyte.
Studies of lipid, carbohydrate, protein, and collagen metabolism as well as the
liver drug metabolizing system and liver cell transport processes are under
active investigation. Many of the projects are collaborative and some closely
interact with independently funded new research programs encouraged by the
success of the LMPP. Most projects have utilized the cell culture core facility
which has developed improved techniques for hepatocyte monolayer culture. This
relatively new methodology has been exploited to advance understanding of
metabolic and transport processes and to verify or confirm observations from
other techniques, in vitro or in vivo. The emphasis during the renewal period
will concern the following metabolic functions: synthesis of phospholipids and
neutral lipids in response to toxins and physiological changes, control of bile
acid synthesis, metabolism of liver collagen, the biosynthesis and turnover of
hepatic cytochromes, the regulation of hepatic gluconeogenesis, the formation of
complement proteins and the effects of agents including bile acids on transport
functions of the hepatocyte. The project has: advanced knowledge of liver
metabolism; attracted investigators from other fields into studies of the liver;
and contributed to better exploitation of hepatic monolayer culture for
metabolic studies.
StatusFinished
Effective start/end date5/1/764/30/86

Funding

  • National Institutes of Health

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folic acid
hepatocytes
liver
metabolism
collagen
synthesis
gluconeogenesis
bile acids
lipids
cytochromes
research projects
research programs
pharmacokinetics
phospholipids
cell culture
toxins
proteins
methodology
biosynthesis
carbohydrates

ASJC

  • Medicine(all)