Laser Spectroscopy of the Cornea

Project: Research project

Project Details


DESCRIPTION: (Applicant's Abstract) Dr. Roy Chuck is an M.D., Ph.D. who
obtained his degrees from Columbia University under auspices of the National
Institutes of Health's prestigious Medical Scientist Training Program Prior to
that he obtained an Engineering Science degree from the University of
California al Berkeley. He possesses a unique background that encompasses the
fields of laser spectroscopy, biochemistry and ophthalmology.

The long term objective of this application is to characterize the
spectroscopic properties of the cornea during ultraviolet laser ablation to
allow identification of spectral features that ma3 differentiate normal from
diseased tissue. Specifically, this will be accomplished by the measurement of
laser-induced fluorescence in real-time during 193-nm excimer laser corneal
surger3 in various normal and disease states including chemical burns and

All of the data taken together, besides enhancing our knowledge of the spectral
features of the cornea in various disease states of ocular health, may also
result in the bioengineering development of an instrument to guide the
alteration of excimer laser ablative patterns to achieve more predictable
surgical results by using real-time spectroscopic feedback information.

Much of the work will be accomplished at the Beckman Laser Institute at the
University of California, Irvine which is well equipped to support the in vivo
and clinical studies of excimer laser corneal surgery and vision within this
research program. The Beckman Laser Institute which is located quite close to
the department offices is closely affiliated with the Department of
Ophthalmology. Housed within the Beckman Laser Institute is a clinical excimer
laser that will be used for this study (VISX Star2). In addition, the Beckman
Laser Institute contains a fully equipped vivarium for housing of rabbits, the
experimental animal that will be used in these investigations Core histology
and ultrastructure facilities are also available within the institute.

The UCI Department of Ophthalmology has an active cornea and external disease
service. This clinical practice will provide the patients for the clinical
studies in the final phase of this research.
Effective start/end date5/1/014/30/02


  • Instrumentation
  • Atomic and Molecular Physics, and Optics
  • Dermatology
  • Ophthalmology
  • Optometry