Interdisciplinary protein engineering approach to design high affinity antibodies for flaviviruses

Project: Research project

Project Details

Description

Project Narrative Engineered antibodies present a new treatment modality for viruses to circumvent major obstacles presented by the existence of various serotypes in certain viruses, and to address the development of engineered antibodies that can cross-react related viruses. These two applications are the focus of this interdisciplinary proposal, where a computational residue-based pharmacophore description of the monoclonal antibody interface is used to direct phage display experiments in order to identify broadly neutralizing or cross-reacting antibodies against dengue and Zika viruses.
StatusActive
Effective start/end date11/15/1810/31/22

Funding

  • National Institute of Allergy and Infectious Diseases: $417,500.00
  • National Institute of Allergy and Infectious Diseases: $345,444.00
  • National Institute of Allergy and Infectious Diseases: $417,500.00
  • National Institute of Allergy and Infectious Diseases: $72,056.00
  • National Institute of Allergy and Infectious Diseases: $417,500.00

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