Project Narrative/Relevance New technology that allows the classification of thousands of gut microbial features has made it possible to identify the many physiological and metabolic processes through which microbiota may influence the health of their hosts. Evidence from animal experiments and feeding studies has suggested that microbiota may modulate the risk of diabetes, although few prospective studies have been conducted to establish the relationship between gut microbiome and diabetes incidence. This study aims to examine microbiota composition, functional potential, and fecal metabolome in relation to the risk of developing diabetes in two well-established cohorts of U.S. men and women with complementary ethnic and socioeconomic backgrounds. Study findings will help identify novel microbial features as targets for developing individualized prevention and intervention strategies to alleviate the increasing societal and healthcare burden of diabetes.
|Effective start/end date||1/19/21 → 12/31/22|
- National Institute of Diabetes and Digestive and Kidney Diseases: $669,600.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $547,270.00
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