HEPATITIS CIRRHOSIS CENTER

  • Burk, Robert D. (PI)
  • Sninsky, John (PI)
  • Lieberman, Harvey (PI)
  • Listowsky, Irving (PI)
  • Novikoff, Phyllis (PI)
  • Rauch, Harold (PI)
  • Zern, Mark (PI)
  • Sternlieb, Irmin (PI)
  • Stockert, Richard (PI)
  • Collins, Janna (PI)
  • Rogler, Charles (PI)
  • Shafritz, David (PI)
  • Wolkoff, Allan W. (PI)
  • Aisen, Philip (PI)
  • Peisach, Jack (PI)
  • Chowdhury, Jayanta (PI)
  • Stanley, E. Richard (PI)
  • Gatmaitan, Zenaida (PI)
  • Mitchel, Yale (PI)
  • Fajan, T. (PI)
  • Condeelis, John (PI)
  • Arias, Irwin (PI)
  • Glaser, Joy (PI)
  • Rosenstreich, David (PI)
  • Rifici, Vicent (PI)
  • Bhargava, Madhu (PI)
  • Seifter, S.A.M. (PI)
  • Eder, Howard (PI)
  • Gupta, Raj (PI)
  • Spray, David (PI)
  • Reid, Lola (PI)
  • Goldfischer, Sidney (PI)
  • Levine, Walter (PI)
  • Das, Kiron (PI)
  • Czaja, Mark J., (PI)
  • Stanley, E. Richard (PI)
  • Fajan, T. (PI)
  • Seifter, S.A.M. (PI)

Project: Research project

Description

The Liver Research Center involves 30 major investigators in 8 departments
at the Albert Einstein College of Medicine, and collaborations at 6 other
institutions. Our emphasis is to bridge the gap between advances in basic
biology and their application to liver physiology and disease processes.
Since the Liver Research Center was established and funded in 1977, the
program has expanded in space, faculty, projects, administrative and
educational efforts, and research funding. The Liver Research Center is
now a major interdisciplinary activity at the Albert Einstein College of
Medicine. Research efforts focus on mechanisms of liver cell injury and
regeneration. Major studies involve effects of hepatitis viruses, metals,
drugs, chemicals, parasites and inheritable disorders; collagen deposition
and prevention, molecular mechanisms of protein synthesis and viral
replication, structural-functional studies, transport at the subcellular
and molecular level and hepatic detoxification. Major studies include (1)
reo virus and biliary atresia; (2) receptors in normal and regenerating
liver; (3) copper toxicity; (4) cDNA probes in study of collagen, ligandin,
and HBsAG m RNAs; (5) development of a novel liver cell culture which
retains differentiated function, and (6) detection of fibrogenesis. Four
core facilities are in operational: Protein Chemistry (Bhargava), Cell
Culture (Reid) Morphology (Goldfischer) and Administrative (Arias/Shea).
New collaborations have been established with outstanding biophysicists at
Bell Labs for NMR studies of liver metabolism. The facilities include 36
well-equipped laboratories, newly renovated 800 sq. ft. Animal Institute,
25-bed Adult Clinical Research Center, Human Heredity Center and Pediatric
Liver Registry. Clinical facilities include a 1100-bed general hospital
and a 400-bed University Hospital. A large diverse patient population
includes many patients with viral, alcoholic, parasitic and inheritable
disorders of the liver.
StatusFinished
Effective start/end date6/1/775/31/89

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Liver
Research
Hepatolenticular Degeneration
Ceruloplasmin
Hepatitis B virus
Transgenic Mice
Collagen
Biliary Atresia
Hepatitis Viruses
Heredity
DNA
Endocytosis
Glutathione Transferase
Hepatitis
Genes
Registries
Liver Diseases
Copper
Hepatocytes
Parasites

ASJC

  • Medicine(all)