Project: Research project

Project Details


In order to support research on basic biology of aging, Harvard Medical
School's Division on Aging and its affiliated institutions propose to
establish an NIA-funded Nathan Shock Basic Biology of Aging Center. The
goals of this proposed Center are to provide state-of-the-art
infrastructure, resources and services for basic scientists to study the
molecular basis of the aging process and the development of age-associated
diseases. More specifically, the research resource cores proposed are
designed to facilitate and further accelerate the aggressive pursuit of
hypotheses concerning the genetics of aging, from the molecule to the
organism. As examples, the Center will support investigations on DNA
instabilities as potential causal factors in cancer and aging, gene
expression changes during aging and disease, and the role of aging and
longevity genes in determining healthy lifespan.

Three Research Resource cores are proposed: (1) Analysis of Gene
Mutations; (2) Gene Transcript Recovery and Gene Development; and (3)
Transgenetic and Genetic Model Systems. In addition to technical services
and resources, these cores will also provide training courses on subjects
in molecular gerontology. In addition, a Research Development Core, will
provide a complete training program for junior faculty interested in aging
research, and encourage senior faculty in other disciplines to consider
applying their expertise to questions in aging, and a program Enrichment
Core will provide administrative oversight, organize workshops and special
seminars, promote utilization of Core facilities, develop an international
network of contacts, and seek long-term permanent sources of funding.
Effective start/end date4/1/976/30/01


  • Aging


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