GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

Project: Research project

Project Details

Description

A family of guanine nucleotide binding proteins, G proteins, function as
receptor effector couplers. Two distinct G proteins, Gs and Gi, couple
stimulatory and inhibitory hormone receptors, respectively, to adenylate
cyclase. A homologous retinal protein, transducin, couples a light
receptor, rhodopsin, to cGMP phosphodiesterase. Go is a G protein of
unknown function recently discovered in brain. We have purified G
proteins, raised antibodies to them, and use these to study the structure,
function, and distribution of specific G proteins. These studies provide
important insights into the mechanism of signal transduction across the
cell membrane.
StatusNot started

Funding

  • National Institutes of Health

ASJC

  • Medicine(all)
  • Cell Biology

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