GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

Project: Research project

Project Details

Description

A family of guanine nucleotide binding proteins, G-proteins, function as
receptor effector couplers. Two distinct G-proteins, Gs and Gi couple
stimulatory and inhibitory hormone receptors respectively to adenylate
cyclase. A homologous retinal protein, transducin, couples a light
receptor, rhodopsin, to cGMP phosphodiesterase. Go is a G-protein of
unknown function recently discovered in brain. We have purified
G-proteins, raised antibodies to them, and used these to study the
structure, function, and distribution of specific G-proteins. We have also
used recombinant DNA methods to isolate cDNA clones for G-protein subunits,
to determine their DNA sequence and primary structure, and to study mRNA
synthesis and structure.
StatusNot started

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases

ASJC

  • Immunology

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