! Narrative The largest risk factor for developing a host of pathologies, most prominently Alzheimer’s disease (AD) and other age-related dementias, is age. How aging-associated cellular impairments affect neurodegeneration is not clear. Here we propose that age related accumulation of large-scale genomic instability in non-neuronal cells promotes senescence. Genomic instability-induced senescent astrocytes could fail to accomplish their neuronal nursing functions and/or acquire neurotoxic properties and be particularly detrimental for AD progression. Our results will help elucidate basic mechanisms of neurodegeneration at old age. !
|Effective start/end date||9/30/20 → 8/31/24|
- National Institute on Aging: $1,781,166.00
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