Project Details
Description
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Narrative
The largest risk factor for developing a host of pathologies, most prominently Alzheimer’s disease (AD) and other
age-related dementias, is age. How aging-associated cellular impairments affect neurodegeneration is not
clear. Here we propose that age related accumulation of large-scale genomic instability in non-neuronal cells
promotes senescence. Genomic instability-induced senescent astrocytes could fail to accomplish their neuronal
nursing functions and/or acquire neurotoxic properties and be particularly detrimental for AD progression. Our
results will help elucidate basic mechanisms of neurodegeneration at old age.
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Status | Active |
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Effective start/end date | 9/30/20 → 8/31/24 |
Funding
- National Institute on Aging: $1,781,166.00
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