GENES MEDIATING CELL COMPETITION AND SURVIVAL

Project: Research project

Project Details

Description

DESCRIPTION (adapted from investigator's abstract): Both cell division and
programmed cell death are thought to reflect competition for survival among
normal cells. Dynamic equilibrium between proliferation and death may be
essential to growth control, permitting both homeostasis under varying
growth conditions and changes in tissue size and shape at particular
developmental stages. In this view cell competition and the parameters that
regulate it should be responsible for defining size and shape. Here it is
proposed to identify the molecular mechanisms of cell competition in vivo by
performing genetic screens for Drosophila mutations that prevent cell
competition from occurring. Identification of such genes will provide a
basic understanding of size and shape regulation during growth, in
developmental disorders including cancer and neurodegenerative diseases, and
of morphological changes during evolution.
StatusFinished
Effective start/end date5/1/984/30/99

Funding

  • National Institute of General Medical Sciences

ASJC

  • Cell Biology

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