GENERAL CLINICAL RESEARCH CENTER

EXCEED THE SPACE PROVIDED. This is an application for a five year renewal of the General Clinical Research Center (GCRC) at the University of Pennsylvania Medical Center. The GCRC is used as a multidisciplinary resource within the institution. Investigators from the Departments of Medicine, Surgery, Obstetrics and Gynecology, Epidemiology and Biostatistics, Molecular and Cellular Engineering, Dermatology, Psychiatry, Neurology, Radiology, Physical Medicine and Rehabilitation, Biochemistry, Pharmacology, and Pediatrics are represented in current protocols. The University has fostered translational research by the development of transdepartmental Centers and Institutes. Amongst those active in the GCRC are the Institute for Human Gene Therapy (IHGT), the Center for Experimental Therapeutics (GET), the Center for Epidemiology and Biostatistics, the Center for Sleep and Respiratory Neurobiology, the Center for Womens' Health, the Institute for Neurosciences, and the Functional Brain Imaging Center for the Study of Mental Disorders. Several of these entities, such as the IHGT and the GET have been founded since the last renewal and have become major users of the GCRC. A core laboratory provides diversified analytical support for protocols performed on the GCRC, as do dietetic services and the metabolic kitchen. There is a core CDMAS, which is also utilized by investigators from the Children's Hospital GCRC. Increasingly,the GCRC is used as a focal point for teaching programs focused on patient-oriented medical research involving medical students, residents and fellows. Thus, the GCRC at the University of Pennsylvania plays a central arid critical role in translational and clinical research and in the training of new investigators in patient-oriented research at the institution. University of Pennsylvania Medical Center (UPMC) General Clinical Research Center 3400 Spruce Street 160 DullesPavilion Philadelphia, PA 19104-4283 KEY PERSONNEL See instructions on Page Name Asbury, Arthur K. M.D. FitzGerald, Garret, M.D. Rader, Daniel, M.D. Teff, Karen, Ph.D. Tovvnsend, Raymond, M.D. il.use continuation pages as needed to provide Organization Dean, School of Medicine UPMC UPMC,GCRC UPMC, GCRC UPMC, GCRC UPMC, GCRC PHS 398 (Rev. 4/98) Page 2 002/1 the required information in the format shown below. Role on Project Principal Investigator Program Director Associate Program Director Associate ProgramDirector Associate Program Director BB"