Project: Research project

Project Details


Continuing partial support is requested for an Outpatient General
Clinical Research Center which will be available to investigators from
a wide variety of clinical and population-based departments at the Johns
Hopkins University School of Medicine, School of Hygiene and Public
Health, and School of Nursing. The center will provide facilities for
examination of study participants, funding of selected laboratory
determinations, and assistance with study design and analysis. Emphasis
will also be placed on the training of clinical investigators. The
latter will include provision of targeted training opportunities for
medical students, residents, post-doctoral fellows, nurses, and junior
faculty members as well as provision of training by individual
investigators and their research teams. Access to the center and
distribution of resources will be overseen by an Advisory Committee
appointed by the Principal Investigator.

Major areas of investigation will include the study of infectious
diseases (HIV virus, Herpes Simplex, human papilloma virus, Hepatitis C,
and infectious endocarditis); cardiovascular diseases (prediction and
recognition of ischemic heart disease in asymptomatic individuals,
etiologic factors in coronary artery disease, pathogenesis of ischemic
heart disease, HIV cardiomyopathy, and the value of interventions of
primary, secondary, and tertiary prevention of cardiovascular disease and
cardiovascular disease risk factors; neuro-psychiatric disease
(amyotrophic lateral sclerosis, neuro-AIDS, dementia, autism,
Huntington's disease, bi-polar illness, and the role of the sympathetic
nervous system in pain); genetic diseases (Marfan Syndrome, craniofacial
disorders, and Adrenoleukodystrophy); metabolism and endocrinology
(diabetes mellitus, Albright's hereditary osteodystrophy, and
organ-specific effects of thyroid hormone analogues); oncology (medullary
thyroid carcinoma and breast cancer); renal disease (pathogenesis of
idiopathic nephropathy, predictors of decline in renal function,
long-term sequelae of uninephrectomy, and the value of non-pharmacologic
and drug therapy in the prevention of decline in renal function);
rheumatology (Sjogren's Syndrome and pregnancy in Systemic Lupus
Erythematosus); ophthalmology (retinopathy of diabetes mellitus and
Sickle Cell disease); hematology (pathogenesis and treatment of Sickle
Cell disease); geriatrics (markers of functional decline in aging);
nutritional studies (phenylalanine metabolism and physiological
mechanisms of control of human eating behavior).
Effective start/end date12/1/92 → 11/30/93


  • Endocrine and Autonomic Systems
  • Critical Care and Intensive Care Medicine
  • Clinical Neurology
  • Nephrology
  • Cardiology and Cardiovascular Medicine
  • Neurology
  • Urology
  • Microbiology (medical)
  • Infectious Diseases
  • Anesthesiology and Pain Medicine
  • Molecular Medicine
  • Critical Care
  • Hematology
  • Physiology
  • Pulmonary and Respiratory Medicine
  • Anatomy
  • Virology
  • Rheumatology
  • Immunology and Allergy
  • Neuropsychology and Physiological Psychology
  • Safety, Risk, Reliability and Quality
  • Medical Laboratory Technology
  • Pharmacology (medical)
  • Medical–Surgical
  • Oncology
  • Cancer Research
  • Epidemiology
  • Pediatrics, Perinatology, and Child Health
  • Strategy and Management