GENE CHANGES AND CHEMOTHERAPY FOR COLON CANCER

Project: Research project

Project Details

Description

This renewal application is being submitted after the 1st year of funding
under the R03 mechanism. The goal is to establish the value of genetic
alterations in predicting the natural history and responsiveness to
adjuvant chemotherapy of Dukes' B and C colon cancer utilizing patient
material from cooperative group trials.

In the 1st year of limited funding, we made significant progress in 2
areas: first, the experiments were formally adopted as Eastern
Cooperative Oncology Group (ECOG) protocol EST 5290, establishing
mechanisms for sample acquisition, and data recording, submission and
statistical analysis by the ECOG statistical component at the Dana
Farber; second,, we rigorously determined the level of c-myc copy number
in the DNA from over 324 clinical samples (tumor+normal) encompassing 139
patients entered on ECOG protocol EST 2284, and began to collect samples
from ECOG protocol EST 2288 (301 patients thus far accrued to our
protocol from a total accrual to the parent protocol of 874 ECOG patients
and 2592 in the Intergroup study; total projected accrual to
ECOG/Intergroup approx. 900/2700, respectively, which will
yield greater than 3,000 samples).

The specific aims of this renewal application are similar to those
originally funded as a small pilot project: to determine the prognostic
value of amplifications of c-myc and structural alterations (mutations
and deletions) at 17pl2 (the p53 gene) and 18q2l (the DCC gene) in both
the natural history of Dukes' B and C colon tumors and in predicting
outcome with adjuvant therapy. Analysis of DNA from tumors of a recently
completed ECOG/Intergroup protocol (EST 2284) will be used to develop a
statistical model which will be tested prospectively in a second,
on-going, ECOG/Intergroup protocol (EST 2288) of adjuvant therapy.
StatusFinished
Effective start/end date9/10/927/31/93

Funding

  • National Cancer Institute

ASJC

  • Genetics(clinical)
  • Oncology(nursing)
  • Oncology
  • Cancer Research
  • Pathology and Forensic Medicine

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