Project Details
Description
Cardiovascular disorders remain the number one cause of mortality in United States, with ischemic cardiac
disease as the major sequela underlying such lethality. This is the first investigation into the functional role of
intracellular calcium fluxes in cardiac fibroblasts using a specific and novel animal model in which all isoforms of
a main calcium channel are deleted. Our studies, relevant to public health and to the NIH mission to discover
basic mechanisms underlying human disease, suggest an unprecedented role for intracellular calcium release
channels in the pathophysiology of cardiac fibrosis following myocardial infarction via pathways that involve the
activation and persistence of myofibroblasts after ischemic injury.
Status | Active |
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Effective start/end date | 7/1/19 → 6/30/22 |
Funding
- National Heart, Lung, and Blood Institute: $417,500.00
- National Heart, Lung, and Blood Institute: $417,500.00
- National Heart, Lung, and Blood Institute: $417,500.00
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