FAT REDUCTION AND RISK OF BENIGN BREAST DISEASE

Project: Research project

Project Details

Description

DESCRIPTION: This proposed study is to evaluate the feasibility of
studying women participating in the Dietary Modification (DM) and the
calcium/vitamin D supplementation (CaD) components of the WHI clinical
trial (excluding those who are also in the HRT component) to test the
hypothesis that adoption of a low-fat dietary pattern is associated with
reduced risk of proliferative forms of benign breast disease.
Additionally, it is proposed that CaD alone, and in combination with low-
fat dietary pattern, will also be associated with reduced risk. Also, it
is proposed to conduct a nested case-control analysis of risk factors for
proliferative forms of benign breast disease using cases identified in the
control arms of the DM and CaD components of the trial. The feasibility
study will run for 15 months, including 1 month to generate clinic-
specific lists of eligible patients and to train clinics in the study
methods, 12 months to conduct the review, and 2 months for data analysis.
If the proposed study is feasible, the application predicts that it has
the potential to provide insight into the etiology of the putative pre-
malignant forms of benign breast disease and might identify an avenue for
its prevention.
StatusFinished
Effective start/end date7/22/987/31/08

Funding

  • National Institutes of Health: $733,164.00
  • National Cancer Institute: $918,380.00
  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute: $1,082,472.00
  • National Cancer Institute: $707,333.00
  • National Cancer Institute: $710,268.00

ASJC

  • Medicine(all)
  • Oncology
  • Cancer Research

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