Eradicating persistent M. tuberculosis by synthetic lethality of terminal respiratory oxidases

Medicine & Life Sciences

1. 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl) imidazo(1,2-a)pyridine-3-carboxamide 79%
2. Adenosine Triphosphate 9%
3. Animal Models 8%
4. Anti-Bacterial Agents 7%
5. Anti-Infective Agents 12%
6. bedaquiline 19%
7. Communicable Diseases 10%
8. Cytochrome Reductases 18%
9. Cytochromes 69%
10. Drug Resistance 11%
11. Drug Therapy 7%
12. Electron Transport 26%
13. Electron Transport Complex III 51%
14. Electron Transport Complex IV 57%
15. Enzymes 6%
16. Granuloma 37%
17. Homeostasis 8%
18. In Vitro Techniques 5%
19. Infections 5%
20. Lung 13%
21. Maintenance 8%
22. Mycobacterium tuberculosis 94%
23. Nutrients 10%
24. Oxidation-Reduction 34%
25. Oxidative Phosphorylation 13%
26. Oxidative Stress 8%
27. Oxidoreductases 22%
28. Oxygen 17%
29. Pharmaceutical Preparations 35%
30. Pharmacokinetics 9%
31. Standard of Care 11%
32. Structure-Activity Relationship 14%
33. Synthetic Lethal Mutations 17%
34. Tuberculosis 100%