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Eradicating persistent M. tuberculosis by synthetic lethality of terminal respiratory oxidases
Berney, Michael
(PI)
Microbiology & Immunology
Project
:
Research project
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Medicine & Life Sciences
Synthetic Lethal Mutations
100%
Tuberculosis
62%
Oxidoreductases
62%
6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl) imidazo(1,2-a)pyridine-3-carboxamide
38%
Cytochromes
38%
Mycobacterium tuberculosis
37%
Electron Transport Complex IV
30%
Electron Transport Complex III
27%
Oxidation-Reduction
18%
Granuloma
17%
Pharmaceutical Preparations
17%
Electron Transport
14%
Metabolic Networks and Pathways
12%
bedaquiline
10%
Lung
10%
Oxygen
8%
Cytochrome Reductases
7%
Standard of Care
6%
Structure-Activity Relationship
5%
Nutrients
5%
Oxidative Phosphorylation
5%