Project: Research project

Project Details


The principal goal of this proposal is to define the anatomical
structures and neural activity that underlie the surface recorded
Event Related Potentials (ERP) associated with sensory, motor
and cognitive processes. These studies utilize unanesthetized,
behaving old world monkeys (M. fascicularis), as the closest
feasible model for human ERP. After surface mapping of the
specific ERP under study, depth recordings are employed to
localize the intracranial generators and to define through three-
dimensional intracerebral mapping, the relationship between field
potentials recorded in the immediate vicinity of the active
structures and the surface recorded potentials, which usually
represent composite activity from more than one structure. The
neural processes within each active structure are further
delineated by concurrent recording of field potentials and MUA
from closely spaced electrodes, utilizing a moveable multicontact
electrode of our own design. Local outward and inward neural
transmembrane current flows are estimated from the field
potential data, utilizing current source density analysis.
Identification of active structures and delineation of regions of
enhanced neural metabolism within the structures under
electrophysiological analysis is achieved by 2-Deoxyglucose
autoradiography prior to sacrifice of each animal. Efforts will be
made to identify the neurotransmitters involved in generation of
specific ERP features. The initial focus is on the role of GABA in
intracortical inhibitory circuitry, employing localized
intracortical injections of the GABA antagonist bicuculline. This
endeavor will be facilitated by immunocytochemical examination
of the distribution of specific neurotransmitters within the brain
structures under elecrophysiologic study. Studies will focus on
stimulus related laminar patterns of evoked response in striate
and extrastriate visual cortex, cerebral activity associated with
trained self-initiated hand movements and the potentials related
to the performance of visual and auditory discrimination tasks.
Effective start/end date1/1/901/1/90


  • National Institute of Mental Health


  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Developmental Neuroscience
  • Behavioral Neuroscience

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