EASTERN COOPERATIVE ONCOLOGY GROUP

  • Sparano, Joseph A. (PI)
  • Wiernik, Peter (PI)
  • Wiernek, Peter (PI)
  • Dutcher, Janice (PI)
  • Wadler, Scott (PI)

Project: Research project

Description

The Albert Einstein Cancer Center has been and continues to be a
major scientific resource for ECOG, providing pilot study data for
the initiation of new ECOG clinical trials and providing laboratory
resources for correlative studies. During the past grant period,
ECOG studies in lymphoma, leukemia, breast, head and neck, melanoma
and GI malignancies have been initiated based on pilot work from
Einstein. Two of Einstein's investigators have obtained RO1
funding for laboratory research related to ECOG clinical trials,
and Einstein has initiated 3 laboratory-based correlative studies
in the leukemias, 1 in colon cancer and 1 in cervical cancer with
partial funding provided by Einstein itself. Einstein has
developed 3 core laboratories for ECOG: 1) immunophenotyping
reference lab; 2) molecular biology of differentiation related to
retinoic acid in leukemia; and 3) molecular biology of bcr-abl in
ALL. Einstein, as a tertiary care facility, has maintained its
accrual level, with 167 patients entered (140 from main
institution) from 7/1/91 -6/30/92, and 391 patients continuing in
follow-up. Forty to 52% of patients entered into clinical trials
at Einstein are from minority races which in part reflects the
efforts made by the institution to recruit such patients into
clinical research trials utilizing minority race staff to encourage
participation. More than 50% of study participants are women, and
Einstein has developed ECOG studies specifically for malignancies
of women. An Einstein investigator is the chair of the Gyn Onc
Working Group. Einstein investigators have chaired 13 ECOG studies
during the past grant period and 5 Einstein investigators have held
disease or modality committee leadership roles (chair or co-chair)
during the last grant period. The Einstein CGOP, which includes
another major university center (SUNY-Stonybrook) and a large
hospital in Long island (Nassau County Medial Center) and one in
the Bronx (Our Lady of Mercy) has been productive participants in
ECOG, in terms of accrual to studies and groupwide meeting
attendance.
StatusFinished
Effective start/end date6/1/782/28/14

Funding

  • National Institutes of Health: $244,231.00
  • National Institutes of Health: $101,749.00
  • National Institutes of Health: $137,028.00
  • National Institutes of Health: $151,590.00
  • National Institutes of Health: $159,358.00
  • National Institutes of Health: $156,694.00
  • National Institutes of Health: $138,288.00
  • National Institutes of Health: $127,404.00
  • National Institutes of Health: $160,723.00
  • National Institutes of Health: $144,167.00
  • National Institutes of Health: $99,689.00
  • National Institutes of Health: $178,493.00

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Neoplasms
Research Personnel
Leukemia
Breast Neoplasms
Breast
Medicine
Manuscripts
Organized Financing
Translational Medical Research
Standard of Care
Committee Membership
Research
Clinical Trials
Medical Oncology
Publications
Therapeutics
Medical Faculties
Neck
Mouth Neoplasms
Head

ASJC

  • Medicine(all)