• Qi, Qibin (CoPI)
  • Rose, Susan A. (PI)
  • Rose, Susan A. (PI)

Project: Research project

Project Details


DESCRIPTION: This new application presents plans to study, prospectively,
the association between dietary patterns and risk of coronary heart disease
(CHD), ischemic stroke, and hemorrhagic stroke in cohort studies of 121,700
women age 30 to 55 years at baseline in 1976 (the Nurses; Health Study; NHS)
and 51,529 men aged 40-75 years at baseline in 1986 (the Health
Professionals Follow-up Study; HPFS). Food consumption data were collected
through semiquantitative food frequency questionnaires at baseline and
during follow-up in each of the cohorts. Dietary patterns are derived from
the food consumption data using factor analysis, cluster analysis, and
dietary indexes (based on prevailing dietary recommendations). In addition,
using existing datasets from dietary validation studies in sub-samples of
the two cohorts, the investigators propos to evaluate the reproducibility
and validity of dietary patterns defined by factor/cluster analysis and
dietary indexes. Further, using prospectively collected and stored bloods
in the NHS (n-32, 826) during 1989-1990 and the HPFS (n-18, 000) during
1993-1994, we propose to examine whether observed associations between
dietary patterns and CHD are explained by (or mediated through) plasma
biochemical measurements (including serum lipids, thrombotic factors,
antioxidants, fasting insulin, and homocysteine levels) in a nested
case-control design; and they propose to assess prospectively the
relationship between dietary patterns and these biomarkers in the control
samples. The funded NHS and HPFS will provide follow-up and documentation
of CHD and stroke in addition to covariate information. Assays of
biomarkers in the two cohorts are funded through other grants. Overall, the
large size of these cohorts, the prospective design, the high follow-up
rates, and the availability of archived blood specimens provide a unique
opportunity to study the relationship between overall dietary patterns and
cardiovascular disease in an extremely cost-efficient manner. This would be
the first study to characterize dietary patterns in large cohorts of men and
women and relate dietary patterns to CHD and stroke. Finally, this project
will enable evaluation of prevailing dietary recommendations in relation to
both biomarkers of risk as well as clinical cardiovascular diseases.
Effective start/end date8/1/983/31/22


  • National Heart, Lung, and Blood Institute: $619,027.00
  • National Heart, Lung, and Blood Institute: $705,808.00
  • National Heart, Lung, and Blood Institute: $667,451.00


  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Medicine(all)
  • Molecular Biology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism


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