DEVELOPMENT OF NEW LIPOPHILIC CISPLATIN ANALOGUES

Project: Research project

Project Details

Description

New lipophilic cis-platinum analogues that are non-nephrotoxic and have a
broader spectrum of antitumor activity will be synthesized and formulated
entrapped in liposomes of different composition and size. The toxicity,
pharmacology, tumor uptake, cellular effect and antitumor activity of a
few prototype liposomal-platinum preparations will be studied and
compared with those of cis-platinum, the most promising second and third
generation platinum complexes, and the non-entrapped compounds. The
evaluation of liposomal-platinum for the targeted therapy of liver and
lung metastases will receive particular attention. The cellular
mechanisms involved in the increased cytotoxicity of liposomal-platinum
will be studies in human cell lines sensitive and resistant to platinum
derivatives. The study will define the potential clinical application of
liposomes as carriers of platinum complexes and will result in the
development of liposomal-platinum preparations for clinical use. The
information generated will be essential in improving the design and use
of drug carriers for antitumor agents.
StatusFinished
Effective start/end date1/1/906/30/90

Funding

  • National Cancer Institute

ASJC

  • Cancer Research

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