Project: Research project

Project Details


Clinical studies have suggested that over 80% of cases of dementia in
subjects over age 85 are due to Alzheimer's disease (AD), but
clinicopathologic studies which assess the etiology of dementia in the
oldest-old (subjects over 85) as well as the pathology of cognitively
normal elderly are lacking. Over the past decade, we have performed
prospective clinicopathological studies on over 86 elderly subjects who had
been assessed with yearly neuropsychological testing. Our data suggest
that a majority of cases of dementia in the oldest-old are not due to AD.

In this renewal application, we propose to continue our clinicopathologic
studies to describe the neuropathology of normal elderly and to determine
the pathologic substrate of dementia in the oldest-old. We will utilize
the expanded population in the clinical core, and estimate that we will be
able to complete an additional 85 clinicopathologic studies by 1997. To
test the hypothesis that dementia is associated with synapse loss and white
matter pathology we will perform quantitative measures of synapse-
associated proteins and galactolipids in standardized sections of cortex
and white matter. We will then measure the association of these
pathological variables with clinical measures such as memory test scores
and VIQ.

Because sensitivity and specificity of diagnosis of dementia subtype is
poor in elderly subjects, we will analyze our autopsy proven cases to
determine which clinical signs or pattern of scores on standard and
experimental neuropsychological tests will improve diagnostic accuracy. We
will test the hypothesis that cardiac ischemia is associated with ischemic
dementias by performing 24 hour ambulatory EKGs in controls and subjects
with different types of dementia.
Effective start/end date1/1/015/31/21


  • Clinical Neurology
  • Neurology
  • Psychology(all)
  • Statistics and Probability
  • Neuroscience(all)
  • Nursing(all)
  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine
  • Genetics
  • Medicine(all)
  • Physiology
  • Cell Biology
  • Pathology and Forensic Medicine
  • Rheumatology
  • Statistics, Probability and Uncertainty
  • Ecology


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