Defining the impact of mutational drivers on the immune microenvironment of CLL

Project: Research project

Project Details


Project Narrative Tumor immune landscapes differ greatly amongst individual patients and affect immunotherapy response. However, the impact of cancer genetics on the heterogeneity in immune landscapes has not been systematically explored, and we are still lack clear understanding of these microenvironmental changes. Our mechanistic studies in novel mouse models that can mimic the vast genetic heterogeneity of human chronic lymphocytic leukemia (CLL) will expand our knowledge on how cancer cell-intrinsic features can remodel the tumor immune microenvironment, and are anticipated to contribute to the rational design of personalized cancer immunotherapy.
Effective start/end date2/1/221/31/23


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