Project Details
Description
Project Narrative
Tumor immune landscapes differ greatly amongst individual patients and affect immunotherapy response.
However, the impact of cancer genetics on the heterogeneity in immune landscapes has not been systematically
explored, and we are still lack clear understanding of these microenvironmental changes. Our mechanistic
studies in novel mouse models that can mimic the vast genetic heterogeneity of human chronic lymphocytic
leukemia (CLL) will expand our knowledge on how cancer cell-intrinsic features can remodel the tumor immune
microenvironment, and are anticipated to contribute to the rational design of personalized cancer immunotherapy.
Status | Active |
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Effective start/end date | 2/1/22 → 1/31/23 |
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