CORE--TRANSGENIC

  • Vijg, Jan (PI)
  • Walter, Christi (PI)
  • Firulli, Anthony B. (PI)
  • Herman, Brian A. (PI)
  • Ikeno, Yuji (PI)
  • Strong, Randy (PI)
  • van Remmen, Holly (PI)
  • Hornsby, Peter (PI)
  • Richardson, Arlan G. (PI)
  • Austad, Steven (PI)
  • Reddick, Robert (PI)
  • Walter, Christi (PI)
  • Sharp, Dave (PI)
  • Musi, Nicolas (PI)
  • Javors, Martin (PI)
  • Bowman, Barbara (PI)
  • Yu, Byung (PI)
  • Masoro, Edward (PI)
  • Nelson, James (PI)
  • Firulli, Anthony B. (PI)
  • Herman, Brian A. (PI)
  • Richardson, Arlan G. (PI)
  • Bowman, Barbara (PI)
  • Yu, Byung (PI)
  • Masoro, Edward (PI)
  • Nelson, James (PI)
  • Vijg, Jan (PI)

Project: Research project

Project Details

Description

Transgenic animals give investigators a powerful system for either
targeting the expression of a gene to a specific tissue(s) or obliterating
the expression of a specific gene. Therefore, transgenic animals are an
excellent tool for directly evaluating the role of a specific gene (or
genes) in an age-related disease or in aging. The Transgenic Core will
provide all services and services and resources required to produce
transgenic mice, transgenic rats, and transgenic mice with gene knockouts
for Center investigators. Because the techniques for producing transgenic
rats or mice with gene knockouts are not currently available at UTHSC-SA,
an important goal of this Core is to develop these techniques. The
specific aims of the Core are as follow:

1. To produce transgenic mice by microinjection and to identify the
transgenic mice by PCR and DNA hybridization techniques. The number and
integration sites of the transgene also will be determined by examining DNA
from the transgenic mice.

2. To develop the techniques for producing transgenic rats by
microinjection and to use these techniques to produce transgenic rats for
Center investigators. Transgenic rats will be identified by PCR and DNA
hybridization techniques, and the number and integration sites of the
transgene will be determined.

3. To develop the techniques for producing transgenic mice with gene
knockouts using homologous recombination and to use these techniques to
produce transgenic knockout mice for Center investigators.
StatusActive
Effective start/end date1/1/015/31/22

ASJC

  • Medicine(all)
  • Animal Science and Zoology
  • Public Health, Environmental and Occupational Health
  • Arts and Humanities(all)
  • Cardiology and Cardiovascular Medicine
  • Nephrology
  • Genetics
  • Atomic and Molecular Physics, and Optics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Aging
  • Molecular Biology
  • Biochemistry
  • Physiology
  • Biotechnology
  • Cell Biology
  • Computer Science Applications
  • Pathology and Forensic Medicine
  • Statistics, Probability and Uncertainty
  • Microbiology
  • Pharmacology

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