Project: Research project

Project Details


The aim of this meeting is to bring together scientists studying peptide
processing enzymes and intracellular sorting mechanisms from biochemical,
cell biological, developmental, and genetic perspectives so that a more
comprehensive understanding of the processes will emerge. The range of
topics to be covered at this meeting will be a tremendous learning
experience that will benefit both junior scientists (students and post-
docs) as well as established scientists. Also, this meeting will be held
concurrently with a highly related Keystone meeting, and the joint format
will produce a large number of multidisciplinary interactions.

Many biologically important proteins and peptides are synthesized as
inactive precursors that require proteolytic cleavage to become
biologically active. Recent advances have led to the identification of
several enzymes responsible for these activation steps, and the mechanism
by which proteins are targeted to the correct cellular organelle where
proteolytic processing occurs. In addition, genetic defects with some of
the processing enzymes have recently been identified in humans, mice, and
in lower organisms; these defects cause a variety of physiological changes
including obesity, sterility, and diabetes. Inhibitors of the processing
enzymes are being developed for a wide range of applications including
antiviral agents, antihypertensives, analgesics, and chemotherapeutics.
To understand the complex systems of protein and peptide processing, a
wide array of approaches are needed. One important aspect of this meeting
will be to bring together scientists from different fields, who are
working on the same problems, but using different techniques. Students,
post-docs, and established scientists will benefit from the exposure to
different systems, and the potential for collaborations; through
collaborations, research can be conducted more efficiently, and so NIH
funding is well justified for the meeting.
Effective start/end date3/3/972/28/98


  • Genetics


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